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Medication that inhibit CYP2D6 activity, for example paroxetine and quinidine, may possibly lead to decreased clearance of oxycodone which may lead to an increase in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in an increase in oxycodone Cmax by 11%, AUC by thirteen%, and t½ elim.Patients ought to be titrated t

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